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- Title
Diagnosis and Management of Human B Virus (Herpesvims simiae) Infections in Michigan.
- Authors
Davenport, David S.; Johnson, David R.; Holmes, Gary P.; Jewett, Dennis A.; Ross, Stephen C.; Hilliard, Julia K.
- Abstract
Three men who had worked at the same animal research facility and had had contact with macaque monkeys were infected with B virus (Herpesvims simiae). Their clinical presentations varied from self-limited aseptic meningitis syndrome to fulminant encephalomyelitis and death. Patient 1 was treated only after a respiratory arrest and other signs of advanced brain stem dysfunction had occurred. He died 8 days after hospital admission, despite treatment with acyclovir. Patient 2 presented with subtle signs and symptoms of brain stem encephalitis. He received antiviral therapy with intravenous ganciclovir. Patient 3 had a headache without meningismus and was also treated with acyclovir. Both patients 2 and 3 survived and did not have objective sequelae. Viral culturing, ELISA and western blot antibody testing, and magnetic resonance imaging all proved useful in the diagnosis of these patients' conditions.
- Publication
Clinical Infectious Diseases, 1994, Vol 19, Issue 1, p33
- ISSN
1058-4838
- Publication type
Article