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- Title
A unique array of neuroprotective effects of pyruvate in neuropathology.
- Authors
Zilberter, Yuri; Gubkina, Olena; Ivanov, Anton I.
- Abstract
The authors discuss the characteristics of the neuroprotective effects of pyruvate in neuropathology, focusingon the three common signature traits of several neurological diseases such as brain hypometabolism, oxidative stress and neuroinflammation. Topics include the efficacy of pyruvate in enhancing brain-to-blood glutamate efflux, the role of pyruvate in protecting neurons against H2O2-induced toxicity, and its anti-inflammatory action.
- Subjects
ENERGY metabolism regulation; PYRUVATES; NEURODEGENERATION; OXIDATIVE stress; GLUTAMIC acid; PREVENTION
- Publication
Frontiers in Neuroscience, 2015, Vol 9, p1
- ISSN
1662-4548
- Publication type
Opinion
- DOI
10.3389/fnins.2015.00017