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- Title
Serum level of sCD163, a soluble receptor for hemoglobin, is influenced by cardiac surgery.
- Authors
Kolackova, Martina; Lonsky, Vladimir; Kudlova, Manuela Trojackova; Mandak, Jiri; Kunes, Pavel; Svitek, Vladimir; Jankovicova, Karolina; Vlaskova, Dana; Andrys, Ctirad; Krejsek, Jan
- Abstract
Background: The scavenger receptor for complexes hemoglobin-haptoglobin (CD163), which is expressed on monocytes/ macrophages, is shed to the body fluids in a soluble form (sCD163). Objectives: To evaluate the dynamics of sCD163 in the blood of patients undergoing cardiac surgery. Patients and Methods: Sixty-one adult patients who underwent coronary artery bypass grafting (CABG) were enrolled in the study. They were assigned to undergo CABG using either cardiopulmonary bypass (CPB), "on-pump", (22 patients), modified CPB, mini "on-pump", (17 patients) or without CPB, "off-pump", (22 patients) surgery. Serum levels of sCD163 in venous blood samples taken before and after surgery, and during an early postoperative period, were evaluated by Macro 163™ diagnostic kit (IQ Products, Groningen, NL). Results: Compared to the preoperative levels ("on-pump"; 344 ng/mL, "off-pump"; 314.5 ng/mL, mini-invasive "on-pump"; 336.5 ng/mL) serum levels were elevated at the finish of surgery, reaching maximum at the 1st postoperative day ("onpump"; 658 ng/mL; p<0.05, "off-pump"; 810.5 ng/mL; p<0.01; mini-invasive "on-pump"; 663 ng/mL; non-significant). No significant differences regarding the serum levels of sCD163 between different surgical approaches were found. Conclusion: Serum level of sCD163 scavenger molecule for hemoglobin is elevated at the end of surgery and at the 1st postoperative day, being little influenced by cardiopulmonary bypass.
- Subjects
CARDIAC surgery; BODY fluids; CORONARY artery bypass; POSTOPERATIVE period; CARDIOPULMONARY bypass
- Publication
Perfusion, 2009, Vol 24, Issue 4, p263
- ISSN
0267-6591
- Publication type
Article
- DOI
10.1177/0267659109348723