We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bacterial Methanogenesis Proceeds by a Radical Mechanism.
- Authors
Buckel, Wolfgang
- Abstract
The thiyl radical of cysteine 272 (C272) in the C‐P lyase adds to 5‐phosphoribose‐1‐methylphosphonate to give a covalently bound thiophosphonate radical. Reaction with glycine 32 (G32) of the enzyme yields methane, a glycyl radical, and thiophosphate (see scheme). Intramolecular attack of the 2‐OH group leads to 5‐phosphoribose‐1,2‐cyclic‐phosphate, whereas the glycyl radical oxidizes the liberated SH group back to the thiyl radical.
- Subjects
METHANOGENS; BIOLOGICAL control of bacteria; GENETIC regulation; GLYCINE metabolism; THIYL radicals; LYASE genetics; PYRUVATES; BACTERIA
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 33, p8507
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201304593