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- Title
Effect of Intravitreal Bevacizumab (Avastin<sup>®</sup>) Therapy in Malignant Hypertensive Retinopathy: A Report of Two Cases.
- Authors
Kim, Eui Yon; Lew, Ho Min; Song, Ji Hun
- Abstract
Purpose: Malignant hypertensive retinopathy is a rare, but serious, complication of uncontrolled systemic hypertension for which no treatment has been established yet. We report 2 patients with malignant hypertensive retinopathy who recovered promptly following intravitreal bevacizumab injection. Methods: Intravitreal bevacizumab (1.25 mg/0.05 mL) was injected in 4 eyes of 2 patients having malignant hypertensive retinopathy with optic disc edema, macular edema, and retinal exudates. A complete ophthalmic examination, including the best-corrected visual acuity (BCVA), central macular thickness (CMT) on optical coherence tomography (OCT), and fluorescein angiography (FAG), was performed before and after the treatments. Results: Two eyes in 1 patient received two intravitreal injections of bevacizumab, whereas 2 eyes in the other patient received a single treatment. All 4 eyes had improvement of macular edema on OCT at 1 month and decreased fluorescein leakage on FAG 3 months after the treatment, which led to improvements in the BCVA in 3 eyes. In 1 eye with foveal atrophy, no change in the BCVA occurred despite the improved macular edema on OCT. Conclusions: The results suggest that intravitreal bevacizumab injections might be a useful adjunctive treatment of malignant hypertensive retinopathy in some selected cases. However, further studies are mandatory to determine the safety and the efficacy of such injections in this disease.
- Subjects
DIABETIC retinopathy treatment; BEVACIZUMAB; OPHTHALMIC drugs; OPTICAL coherence tomography; FLUORESCENCE angiography; VISUAL acuity
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2012, Vol 28, Issue 3, p318
- ISSN
1080-7683
- Publication type
Article
- DOI
10.1089/jop.2011.0113