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- Title
The effect of ketamine/xylazine and carbon dioxide on plasma luteinizing hormone releasing hormone and testosterone concentrations in the male Norway rat.
- Authors
Gould, E. M.
- Abstract
The effect of a commonly used anaesthetic, ketamine/xylazine and/or carbon dioxide (CO2) on plasma luteinizing hormone releasing hormone (LHRH) and testosterone concentrations was determined in male Sprague-Dawley rats. These values were compared with values obtained from pre-anaesthetic control samples. Ketamine/xylazine treatment did not significantly affect testosterone concentrations. In contrast, LHRH started to decrease one hour after ketamine/xylazine administration and continued to significantly decrease after 24 h. In addition, in the CO2 euthanasia-only group, LHRH concentrations were also significantly decreased. These results suggest that ketamine/xylazine anaesthesia followed by CO2 euthanasia 24 h later is exerting a significant effect on LHRH concentrations 24 h after anaesthetizing, while only having a slight effect on testosterone, and that CO2 is exerting an immediate significant effect on LHRH. In conclusion, LHRH analysis should be avoided after ketamine/xylazine anaesthesia and CO2 euthanasia.
- Subjects
ANIMAL welfare; KETAMINE; XYLAZINE; LUTEINIZING hormone releasing hormone; TESTOSTERONE; RATS
- Publication
Laboratory Animals, 2008, Vol 42, Issue 4, p483
- ISSN
0023-6772
- Publication type
Article
- DOI
10.1258/la.2007.007090