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- Title
Acute Liver Failure Due to Etodolac, a Selective Cycloxygenase- 2 (COX -2) Inhibitor Non-Steroidal Anti-Inflammatory Drug Established by RUCAM-Based Causality Assessment.
- Authors
Taneja, Sunil; Kumar, Pramod; Rathi, Sahaj; Duseja, Ajay; Singh, Virendra; Dhiman, Radha Krishan; Chawla, Yogesh Kumar
- Abstract
Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepatotoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF. Antibiotics are the most common cause of idiosyncratic DILI as well as DILI induced ALF. Etodolac is a selective cycloxygenase- 2 (COX -2) inhibitor non-steroidal anti-inflammatory drug used as an analgesic and anti-inflammatory in musculoskeletal diseases. Severe liver impairment is extremely rare. Till date, only 3 cases of ALF related to etodolac have been reported in the literature. Here we report two cases with a unique presentation of ALF occurring due to DILI caused by etodolac, as diagnosed by Roussel Uclaf Causality Assessment Method (RUCAM).
- Subjects
LIVER failure -- Risk factors; ETODOLAC; CYCLOOXYGENASE 2 inhibitors; NONSTEROIDAL anti-inflammatory agents; MUSCULOSKELETAL system diseases; HEPATOTOXICOLOGY
- Publication
Annals of Hepatology: Official Journal of the Mexican Association of Hepatology, 2017, Vol 16, Issue 5, p918
- ISSN
1665-2681
- Publication type
Article
- DOI
10.5604/01.3001.0010.2829