We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
CLINICAL RISK FACTORS FOR SKIN CANCER IN A COHORT OF KIDNEY AND HEART TRANSPLANT RECIPIENTS: A CASE CONTROL STUDY.
- Authors
Tessari, G.; Sassi, F.; Boschiero, L.; Forni, A.; Gotti, E.; Pizzagalli, A.; Barba, A.; Naldi, L.
- Abstract
Introduction: Organ transplant recipients are at high risk of skin cancer. Multiple risk factors (iatrogenic immunosuppression, follow-up time, age at transplantation, etc.) have been extensively reported in the literature. Only a few data about Mediterranean and Italian people are available. Methods: A case-control study was developed. From 1997 all the renal (RTR) and heart (HTR) transplant patients with histologically proven skin cancer entered into the present study. Each patient (case) was matched with two transplanted patients with the same type of organ, sex, and follow-up time, but free of skin cancer (controls). After informed consent, a trained dermatologist made a full skin examination and a detailed interview about some possible risk factors (sun exposure for job or leisure, holidays, personal or family history of cancer etc.). T test for independent samples and χ2 test were used for statistical analysis. Multivariate analysis will be made with conditioned logistic regression. Collection of cases and controls is in progress; we present only preliminary data. Results: We collected 229 patients (189 RTR, 40 HTR). They were 91 cases (76M, 15F) and 138 controls (118 M, 20 F). mean age (years) at the visit was 56,9 SD 10,1 (60,8 SD 8,1 cases, 54,3 SD 10.3 controls). Age at transplantation was 47,8 SD 10.5 for cases and 41.0 SD 12.9 for controls (p<0.0001). Mean follow up time (years) was 14,4 SD 9.1. Mean follow up time (years) at the diagnosis of the cancer was 7.4 SD 5.4 (range 0-21.7 years). 41/91 patients had a second cancer after 2.1 SD 2.5 years from the first one and 19/41 had a third cancer. Patients with cancer were more prone to have fair skin (p<0.02), elastosis (p<0.00001) actinic keratoses anywhere (p<0.001), on the face (p<0.008) and on the arms (p<0.005). No differences between cases and controls were found about hair colour (p=0.373) eye colour (p=0.444), solar lentigo (p=0.284), number of nevi on the upper arm (p=0.515). Discussion: Age at transplantation fair skin, actinic keratoses and elastosis are important risk factors for skin cancer among organ transplant recipients. Patients with a first cancer are at high risk for sub-sequent cancers. Further data will be obtained after ending data collection and multivariate analysis. An accurate clinical follow up of all transplanted patient is needed.
- Subjects
CANCER; SKIN cancer; DISEASE risk factors; HEART transplant recipients; TRANSPLANTATION of organs, tissues, etc.; INFORMED consent (Medical law); DERMATOLOGISTS; SKIN diseases
- Publication
Journal of Investigative Dermatology, 2005, Vol 125, Issue 4, p856
- ISSN
0022-202X
- Publication type
Abstract
- DOI
10.1111/j.0022-202X.2005.23877_21.x