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- Title
αvβ6 Integrin Upregulates Matrix Metalloproteinase 9 and Promotes Migration of Normal Oral Keratinocytes.
- Authors
Thomas, Gareth J.; Poomsawat, S.; Lewis, Mark P.; Hart, Ian R.; Speight, Paul M.; Marshall, John F.
- Abstract
The integrin alpha v beta 6 is a fibronectin receptor that is undetectable on normal keratinocytes in situ, but is increased significantly in wound healing and in culture-established keratinocytes, suggesting that it may promote changes associated with cell motility. Using normal human oral keratinocytes we have shown that cultured cells express relatively high levels of alpha v beta 6 and this integrin has a functional role in both cell adhesion and migration towards fibronectin. We provide experimental evidence that the increased expression of alpha v beta 6 by normal human oral keratinocytes results in coordinate changes, which promote a more migratory phenotype. Thus increased expression of alpha v beta 6 results in a fibronectin dependent increase in pro-matrix metalloproteinase 9, matrix metalloproteinase 9 activity increases normal human oral keratinocyte migration, and this may be further dependent on plasmin activation. The results suggest a key role for alpha v beta 6 in these processes and indicate a coordinated link between alpha v beta 6 expression and upregulation of matrix metalloproteinase 9. It appears that alpha v beta 6 may function in normal human oral keratinocyte migration through matrixmetalloproteinase-9-dependent and -independent mechanisms. Key words: integrins/keratinocytes/metalloproteinases/ migration. J Invest Dermatol 116:898-904, 2001
- Subjects
INTEGRINS; KERATINOCYTES; WOUND healing; CELL adhesion
- Publication
Journal of Investigative Dermatology, 2001, Vol 116, Issue 6, p898
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1046/j.1523-1747.2001.01352.x