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- Title
COVID-19 convalescent plasma: Interim recommendations from the AABB.
- Authors
Cohn, Claudia S.; Estcourt, Lise; Grossman, Brenda J.; Pagano, Monica B.; Allen, Elizabeth S.; Bloch, Evan M.; Casadevall, Arturo; Devine, Dana V.; Dunbar, Nancy M.; Foroutan, Farid; Gniadek, Thomas J.; Goel, Ruchika; Gorlin, Jed; Joyner, Michael J.; Metcalf, Ryan A.; Raval, Jay S.; Rice, Todd W.; Shaz, Beth H.; Vassallo, Ralph R.; Winters, Jeffrey L.
- Abstract
By early 2021, over 25,000 units of CCP were transfused every week in the United States (US) to patients with COVID-197 under conditions that varied in regard to the patient's disease severity, timing of the transfusion, and the number of units transfused. Keywords: blood center operations; FFP transfusion; transfusion practices (adult) EN blood center operations FFP transfusion transfusion practices (adult) 1313 1323 11 04/10/21 20210401 NES 210401 INTRODUCTION Convalescent plasma (CP) has been used as passive immunotherapy for the prevention and treatment of infectious diseases for more than 100 years.1,2 The lack of proven therapies during the early months of the COVID-19 pandemic, a favorable safety profile3,4 and early evidence for efficacy in adults5,6 led to the widespread use of CCP. In addition, there are specific patient populations who could possibly benefit, including pediatric patients, pregnant women, immunosuppressed patients, and other populations at high risk for development of severe or critical COVID-19 disease. As COVID cases surge, the supply of CCP has been outstripped by demand, resulting in the need for more thoughtful use so that transfusions are limited to patients for whom CCP is likely to be effective.
- Subjects
CONVALESCENT plasma; COVID-19; BLOOD transfusion reaction; CORONAVIRUS disease treatment; COVID-19 pandemic; MEDICAL personnel
- Publication
Transfusion, 2021, Vol 61, Issue 4, p1313
- ISSN
0041-1132
- Publication type
journal article
- DOI
10.1111/trf.16328