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- Title
Effects of Ethanol on Human Monocyte IgG Fc Receptors.
- Authors
B. Mørland; J. Mørland
- Abstract
The IgG Fc receptor function of human monocytes (Mo) exposed to ethanol in vitro was assessed by a rosette assay in which IgG-coated sheep red blood cells were used as test particles. Pre-incubation of Mo in autologous serum with ethanol (55 mM and above) for 15 mm at 37° C, caused a significantly lower percentage of Mo-forming rosettes. This reduction by ethanol was not observed when Mo were preincubated with ethanol in fetal calf serum or in serum-free conditions, but was present when Mo were pre-incubated with ethanol in serum-free media to which IgG (10-150 μg/ml) had been added. Donor-dependent differences were observed in the reduction of Mo-forming rosettes in the presence of autologous serum and ethanol. Mo allowed to form rosettes without ethanol were exposed to ethanol during a subsequent phagocytosis process. A dose-dependent inhibition of the internalization of test particles was found in Mo from all donors.
- Subjects
PHYSIOLOGICAL effects of alcohol; IMMUNOGLOBULIN G; ERYTHROCYTES; SERUM; PHAGOCYTOSIS; SERUM-free culture media
- Publication
Scandinavian Journal of Immunology, 1987, Vol 26, Issue 2, p187
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1987.tb02250.x