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- Title
Tumour--Host Interactions in Vivo II. Induction of NK--Cell Activity by Intraperitoneal Injection of Murine Sarcoma Cells or Tumour Ascites Fluid.
- Authors
Gaudernack, G.; Olsland, R.
- Abstract
We have earlier shown that coculture of macrophages and tells from a methylcholanthrene-induced sarcoma (MC1M-AA) in vitro resulted in macrophage activation and production of type II (gamma) interferon. When ascites fluid from the MCIM-AA sarcoma (shown previously lo activate macrophages in vitro) was added to spleen cell populations from semisyngeneic C3D2 mice in vitro. NK activity was markedly enhanced. After intraperitoneal injection of MC1M-AA cells or ascites fluid, 4- to l2-rokl increased NK cell activity with a peak at 3-5 days could be measured in the spleen cell population and in the non-adherent peritoneal exudate cell population. The mice injected with tumour cells or ascites fluid developed a pronounced splenomegaly, and maximum spleen size coincided with peak NK activity. Injection of tumour cells or tumour ascites fluid resulted in marked changes in the T-cell, B-cell, macrophage, and 'null' cell content of the peritoneal exudates.
- Subjects
TUMORS; MACROPHAGES; LYMPHOID tissue; SARCOMA; INTERFERONS; ASCITES
- Publication
Scandinavian Journal of Immunology, 1983, Vol 17, Issue 3, p375
- ISSN
0300-9475
- Publication type
Article