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- Title
Modulation of the Immune Response by Plasma Protease Inhibitors I. Alpha<sub>2</sub>-Macroglobulin and Alpha<sub>1</sub>-Antitrypsin Inhibit Natural Killing and Antibody-dependent Cell-mediated Cytotoxicity.
- Authors
Ades, E. W.; Hinson, A.; Chapuis-Cellier, C.; Arnaud, P.
- Abstract
The two major protease inhibitors in human serum, alpha1-antitrypsin (α1AT) and alpha2- macroglobulin (α 2m), were analysed for their effects on antibody-dependent cell-mediated cytotoxocity (ADCC) and natural killing (NK). The results indicate that both α 1AT and α 2m decrease ADCC and NK in a dose-responsive pattern.
- Subjects
PROTEASE inhibitors; SERUM; ALPHA 1-antitrypsin; MACROGLOBULINS; ANTIBODY-dependent cell cytotoxicity; DOSE-response relationship in biochemistry
- Publication
Scandinavian Journal of Immunology, 1982, Vol 15, Issue 1, p109
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00628.x