We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Modified Glasgow Prognostic Scores as a Predictor in Diffuse Large B Cell Lymphoma Treated with R-CHOP Regimen.
- Authors
Yundeok Kim; Soo Jeong Kim; Dohyu Hwang; Jieun Jang; Shin-Young Hyun; Yu Ri Kim; Jin Seok Kim; Yoo Hong Min; June-Won Cheong
- Abstract
Purpose: The modified Glasgow Prognostic Score (mGPS) consisting of serum C-reactive protein and albumin levels, shows significant prognostic value in several types of tumors. We evaluated the prognostic significance of mGPS in 285 patients with diffuse large B cell lymphoma (DLBCL), retrospectively. Materials and Methods: According to mGPS classification, 204 patients (71.5%) had an mGPS of 0, 57 (20%) had an mGPS of 1, and 24 (8.5%) had an mGPS of 2. Results: Our study found that high mGPS were associated with poor prognostic factors including older age, extranodal involvement, advanced disease stage, unfavorable International Prognostic Index scores, and the presence of B symptoms. The complete response (CR) rate after 3 cycles of R-CHOP chemotherapy was higher in patients with mGPS of 0 (53.8%) compared to those with mGPS of 1 (33.3%) or 2 (25.0%) (p=0.001). Patients with mGPS of 0 had significantly better overall survival (OS) than those with mGPS=1 and those with mGPS=2 (p=0.036). Multivariate analyses revealed that the GPS score was a prognostic factor for the CR rate of 3 cycle R-CHOP therapy (p=0.044) as well as OS (p=0.037). Conclusion: mGPS can be considered a potential prognostic factor that may predict early responses to R-CHOP therapy in DLBCL patients.
- Subjects
DIFFUSE large B-cell lymphomas; LYMPHOMA treatment; C-reactive protein; BLOOD serum analysis; LYMPHOMAS; PREDICTION theory; PATIENTS; PROGNOSIS
- Publication
Yonsei Medical Journal, 2014, Vol 55, Issue 6, p1568
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2014.55.6.1568