We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts.
- Authors
Siguang Li; Sanna, Serena; Maschio, Andrea; Busonero, Fabio; Usala, Gianluca; Mulas, Antonella; Lai, Sandra; Dei, Mariano; Orrú, Marco; Albai, Giuseppe; Bandinelli, Stefania; Schlessinger, David; Lakatta, Edward; Scuteri, Angelo; Najjar, Samer S.; Guralnik, Jack; Naitza, Silvia; Crisponi, Laura; Cao, Antonio; Abecasis, Goçalo
- Abstract
High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10-16), along with eight others (p = 7.75 x 10-16 to 6.05 x 10-11). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values.
- Subjects
SARDINIA (Italy); CHIANTI (Italy); ITALY; GENES; URIC acid; GOUT; GENETIC polymorphisms; GENETICS
- Publication
PLoS Genetics, 2007, Vol 3, Issue 11, pe194
- ISSN
1553-7390
- Publication type
Article
- DOI
10.1371/journal.pgen.0030194