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- Title
<sup>18</sup>F-FET and <sup>18</sup>F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study.
- Authors
Krpan, Ana Mišir; Hodolič, Marina; Golubić, Anja Tea; Baučić, Maja; Nemir, Jakob; Mrak, Goran; Žuvić, Marijan; Huić, Dražen
- Abstract
Aim To investigate the diagnostic accuracy of O-(2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) and fluoromethyl-(18F)-dimethyl-2-hydroxyethyl-ammonium chloride (18F-FCH) computed tomography (CT) in patients with primary lowgrade gliomas (LGG). Methods The study enrolled patients with magnetic resonance imaging (MRI)-suspected LGG. Patients underwent both 18F-FET and 18F-FCH positron emission tomography (PET)-CT. Brain PET-CT was performed according to standard protocol - 20 minutes after intravenous injection of 185 MBq of 18F-FET and 185 MBq of 18F-FCH PET. Surgery and pathohistological diagnosis were performed in the next two weeks. Results We observed significantly better concordance between tumor histology and 18F-FET PET (weighted Kappa 0.74) compared with both 18F-FCH (weighted Kappa 0.15) and MRI (weighted Kappa 0.00). Tumor histology was significantly associated with 18F-FET (odds ratio 12.87; 95% confidence interval [CI], 0.49-333.70; P = 0.013, logistic regression analysis). Receiver operating characteristic curve analysis comparing 18F-FCH (area under the curve [AUC] 0.625, 95% CI 0.298-0.884) and 18F-FET (AUC 0.833, 95% CI 0.499-0.982) showed better diagnostic properties of 18F-FET (AUC difference 0.208, 95% CI -0.145 to 0.562, P = 0.248). Conclusion Performing PET-CT in patients with newly diagnosed LGG should be preceded by a selection of an appropriate radiopharmaceutical. 18F-FET seems to be more accurate than 18F-FCH in the LGG diagnosis.
- Subjects
MAGNETIC resonance imaging; COMPUTED tomography; RECEIVER operating characteristic curves; POSITRON emission tomography computed tomography; GLIOMAS; TUMOR grading
- Publication
Croatian Medical Journal, 2021, Vol 62, Issue 4, p310
- ISSN
0353-9504
- Publication type
Article
- DOI
10.3325/cmj.2021.62.310