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- Title
Vitamin A concentration in umbilical cord blood of infants from three separate regions of the province of Québec (Canada).
- Authors
Dallaire F; Dewailly E; Shademani R; Laliberté C; Bruneau S; Rhainds M; Blanchet C; Lefebvre M; Ayotte P; Dallaire, Frédéric; Dewailly, Eric; Shademani, Ramesh; Laliberté, Claire; Bruneau, Suzanne; Rhainds, Marc; Blanchet, Carole; Lefebvre, Michel; Ayotte, Pierre
- Abstract
<bold>Background: </bold>Inuit women from Northern Québec have been shown to consume inadequate quantities of vitamin A. This study was conducted to evaluate the prevalence of blood vitamin A deficiency in newborns from 3 distinct populations of the province of Québec.<bold>Methods: </bold>594 newborns were included in this study (375 Inuit newborns from northern Québec (Nunavik), 107 Caucasian and Native newborns from the Lower Northern Shore of the Saint-Lawrence River (LNS) and 112 newborns from Southern Québec where clinical vitamin A deficiency is uncommon). Mothers were recruited at delivery and vitamin A (retinol) was analyzed from umbilical cord blood samples by reversed-phase high-pressure liquid chromatography.<bold>Results: </bold>Nunavik and LNS newborns had significantly lower mean vitamin A concentrations in cord blood compared to Southern Québec participants (15.7 microg/dL, 16.8 microg/dL and 20.4 microg/dL respectively). The differences observed were similar when adjusted for sex and birthweight. Results also showed that 8.5% of Nunavik newborns and 12.2% of LNS newborns were below 10.0 microg/dL, a level thought to be indicative of blood vitamin A deficiency in neonates.<bold>Conclusion: </bold>These data suggest that a carefully planned vitamin A supplementation program during pregnancy in Nunavik and LNS might be indicated to promote healthy infant development.
- Subjects
QUEBEC (Province); CHI-squared test; DIETARY supplements; EPIDEMIOLOGICAL research; CORD blood; FOOD habits; HIGH performance liquid chromatography; INUIT; MEDICAL records; POPULATION geography; PROBABILITY theory; QUESTIONNAIRES; RACE; RESEARCH funding; STATISTICAL sampling; STATISTICS; T-test (Statistics); VITAMIN A; VITAMIN A deficiency; VITAMIN A deficiency in children; WHITE people; DATA analysis; MULTIPLE regression analysis; DISEASE prevalence; CROSS-sectional method; DATA analysis software; DESCRIPTIVE statistics; ACQUISITION of data methodology; CHILDREN
- Publication
Canadian Journal of Public Health, 2003, Vol 94, Issue 5, p386
- ISSN
0008-4263
- Publication type
journal article
- DOI
10.1007/bf03403568