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- Title
Oxygen Delivery Approaches to Augment Cell Survival After Myocardial Infarction: Progress and Challenges.
- Authors
Jenabi, Alireza; Mehdinavaz Aghdam, Rouhollah; Ebrahimi, S. A. Seyyed; Ahmadi Tafti, Seyed Hossein; Krishnan, Sasirekha; Suresh, K. Shoma; Ramalingam, Murugan
- Abstract
Myocardial infarction (MI), triggered by blockage of a coronary artery, remains the most common cause of death worldwide. After MI, the capability of providing sufficient blood and oxygen significantly decreases in the heart. This event leads to depletion of oxygen from cardiac tissue and consequently leads to massive cardiac cell death due to hypoxemia. Over the past few decades, many studies have been carried out to discover acceptable approaches to treat MI. However, very few have addressed the crucial role of efficient oxygen delivery to the injured heart. Thus, various strategies were developed to increase the delivery of oxygen to cardiac tissue and improve its function. Here, we have given an overall discussion of the oxygen delivery mechanisms and how the current technologies are employed to treat patients suffering from MI, including a comprehensive view on three major technical approaches such as oxygen therapy, hemoglobin-based oxygen carriers (HBOCs), and oxygen-releasing biomaterials (ORBs). Although oxygen therapy and HBOCs have shown promising results in several animal and clinical studies, they still have a few drawbacks which limit their effectiveness. More recent studies have investigated the efficacy of ORBs which may play a key role in the future of oxygenation of cardiac tissue. In addition, a summary of conducted studies under each approach and the remaining challenges of these methods are discussed.
- Subjects
MYOCARDIAL infarction; OXYGEN carriers; CELL survival; HEART cells; OXYGEN therapy; OXYGEN in the blood
- Publication
Cardiovascular Toxicology, 2022, Vol 22, Issue 3, p207
- ISSN
1530-7905
- Publication type
Article
- DOI
10.1007/s12012-021-09696-5