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- Title
α-Synuclein aggregation in pathological aging and Alzheimer's disease: The impact of β-amyloid plaque level.
- Authors
Lippa, Sara M.; Lippa, Carol F.; Mori, Hiroshi
- Abstract
In central nervous system diseases, abnormal aggregation of one protein is often associated with aggregation of other proteins. To begin to assess whether β-amyloid (Aβ) is associated with α-synuclein (AS) aggregation [secondary Lewy body (LB) formation], we used immunohistochemical techniques to compare the amygdala of 11 subjects with pathological aging and 18 with Alzheimer's disease. Overall, Aβ-40 plaque level was greater in cases with secondary AS aggregates. Aβ-42 plaque level was not associated with AS aggregation. Aβ-40 plaque levels cannot be ruled out as a factor involved in secondary LB formation.
- Subjects
AMYLOID; IMMUNOHISTOCHEMISTRY techniques; LEWY body dementia; AGING; ALZHEIMER'S disease
- Publication
American Journal of Alzheimer's Disease & Other Dementias, 2005, Vol 20, Issue 5, p315
- ISSN
1533-3175
- Publication type
Article
- DOI
10.1177/153331750502000506