We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hantzsch Ester as Efficient and Economical NAD(P)H Mimic for In Vitro Bioredox Reactions.
- Authors
Guo, Yuan‐Yang; Tian, Ze‐Hua; Han, Yu‐Chen; Ma, Dandan; Shao, Tianju; Jiang, Zhiyong
- Abstract
Biocatalysis has emerged as a valuable and reliable tool for industrial and academic societies, particularly in fields related to bioredox reactions. The cost of cofactors, especially those needed to be replenished at stoichiometric amounts or more, is the chief economic concern for bioredox reactions. In this study, a readily accessible, inexpensive, and bench‐stable Hantzsch ester is verified as the viable and efficient NAD(P)H mimic by four enzymatic redox transformations, including two non‐heme diiron N‐oxygenases and two flavin‐dependent reductases. This finding provides the potential to significantly reduce the costs of NAD(P)H‐relying bioredox reactions.
- Subjects
NAD (Coenzyme); ESTERS; BIOCATALYSIS; REDUCTASES; CHARGE exchange
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 45, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202301180