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- Title
A Vicinal Diol Approach for the Total Synthesis of Molestin E, ent‐Sinulacembranolide A and ent‐Sinumaximol A.
- Authors
Hoff, Oskar; Kratena, Nicolas; Aynetdinova, Daniya; Christensen, Kirsten E.; Donohoe, Timothy J.
- Abstract
In this work an approach for the synthesis of furanocembranoid natural products containing the C‐7,8‐diol moiety is disclosed. This culminated in the first total synthesis of the natural product molestin E, together with ent‐sinulacembranolide A and ent‐sinumaximol A as well as a thorough exploration of their chemistry. Late‐stage ring‐closure of the C‐7,8‐diols to the corresponding epoxides was also demonstrated. Key features of this synthetic strategy include a stereoselective Baylis‐Hillman reaction, ring‐closing metathesis and Shiina macrolactonisation. Chiral‐pool materials were deployed to ensure the desired absolute stereochemistry which was confirmed by late‐stage single crystal X‐ray diffraction.
- Subjects
GLYCOLS; BAYLIS-Hillman reaction; STEREOSELECTIVE reactions; NATURAL products; METATHESIS reactions
- Publication
Chemistry - A European Journal, 2022, Vol 28, Issue 63, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202202464