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- Title
Necroptosis may be a novel mechanism for cardiomyocyte death in acute myocarditis.
- Authors
Zhou, Fei; Jiang, Xuejun; Teng, Lin; Yang, Jun; Ding, Jiawang; He, Chao
- Abstract
In this study, we investigated the roles of RIP1/RIP3 mediated cardiomyocyte necroptosis in CVB3-induced acute myocarditis. Serum concentrations of creatinine kinase (CK), CK-MB, and cardiac troponin I were detected using a Hitachi Automatic Biochemical Analyzer in a mouse model of acute VMC. Histological changes in cardiac tissue were observed by light microscope and expression levels of RIP1/RIP3 in the cardiac tissue were detected via Western blot and immunohistochemistry. The data showed that RIP1/RIP3 was highly expressed in cardiomyocytes in the acute VMC mouse model and that the necroptosis pathway specific blocker, Nec-1, dramatically reduced the myocardial damage by downregulating the expression of RIP1/RIP3. These findings provide evidence that necroptosis plays a significant role in cardiomyocyte death and it is a major pathway for cell death in acute VMC. Blocking the necroptosis pathway may serve as a new therapeutic option for the treatment of acute viral myocarditis.
- Subjects
HEART cells; CELL death; MYOCARDITIS; NECROSIS; BLOOD serum analysis; LABORATORY mice
- Publication
Molecular & Cellular Biochemistry, 2018, Vol 442, Issue 1/2, p11
- ISSN
0300-8177
- Publication type
Article
- DOI
10.1007/s11010-017-3188-5