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- Title
Sensitivity and reproducibility of a new fast 3D segmentation technique for clinical MR-based brain volumetry in multiple sclerosis.
- Authors
Lukas, Carsten; Hahn, Horst; Bellenberg, Barbara; Rexilius, Jan; Schmid, Gebhard; Schimrigk, Sebastian; Przuntek, Horst; Köster, Odo; Peitgen, Heinz-Otto
- Abstract
Fast, reliable and easy-to-use methods to quantify brain atrophy are of increasing importance in clinical studies on neuro-degenerative diseases. Here, ILAB 4, a new volumetry software that uses a fast semi-automated 3D segmentation of thin-slice T1-weighted 3D MR images based on a modified watershed transform and an automatic histogram analysis was evaluated. It provides the cerebral volumes: whole brain, white matter, gray matter and intracranial cavity. Inter- and intra-rater reliability and scan-rescan reproducibility were excellent in measuring whole brain volumes (coefficients of variation below 0.5%) of volunteers and patients. However, gray and white matter volumes were more susceptible to image quality. High accuracy of the absolute volume results (±5 ml) were shown by phantom and preparation measurements. Analysis times were 6 min for processing of 128 slices. The proposed technique is reliable and highly suitable for quantitative studies of brain atrophy, e.g., in multiple sclerosis.
- Subjects
VIRUS diseases; MULTIPLE sclerosis; COMMUNICABLE diseases; MEDICAL virology; DEMYELINATION; MYELIN sheath diseases
- Publication
Neuroradiology, 2004, Vol 46, Issue 11, p906
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-004-1282-3