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- Title
Novel algorithm generating strategy to identify high fracture risk population using a hybrid intervention threshold.
- Authors
Hsu, Chung-Yuan; Wu, Chih-Hsing; Yu, Shan-Fu; Su, Yu-Jih; Chiu, Wen-Chan; Chen, Ying-Chou; Lai, Han-Ming; Chen, Jia-Feng; Ko, Chi-Hua; Chen, Jung-Fu; Cheng, Tien-Tsai
- Abstract
<bold>Introduction: </bold>The aim of this study was to develop an algorithm to identify high-risk populations of fragility fractures in Taiwan.<bold>Materials and Methods: </bold>A total of 16,539 postmenopausal women and men (age ≥ 50 years) were identified from the Taiwan Osteoporosis Survey database. Using the Taiwan FRAX® tool, the 10-year probability of major osteoporotic fracture (MOF) and hip fracture (HF) and the individual intervention threshold (IIT) of each participant were calculated. Subjects with either a probability above the IIT or those with MOF ≥ 20% or HF ≥ 9% were included as group A. Subjects with a bone mineral density (BMD) T-score at femoral neck based on healthy subjects of ≤ - 2.5 were included in group B. We tested several cutoff points for MOF and HF so that the number of patients in group A and group B were similar. A novel country-specific hybrid intervention threshold along with an algorithm was generated to identify high fracture risk individuals.<bold>Results: </bold>3173 (19.2%) and 3129 (18.9%) participants were categorized to groups A and B, respectively. Participants in group B had a significantly lower BMD (p < 0.001), but clinical characteristics, especially the 10-year probability of MOF (p < 0.001) or HF (p < 0.001), were significantly worse in group A. We found the algorithm generated from the hybrid intervention threshold is practical.<bold>Conclusion: </bold>The strategy of generating an algorithm for fracture prevention by novel hybrid intervention threshold is more efficient as it identifies patients with a higher risk of fragility fracture and could be a template for other country-specific policies.
- Subjects
TAIWAN; OSTEOPOROSIS; BONE fractures; BONE density; DUAL-energy X-ray absorptiometry; WORLD Health Organization; DIAGNOSIS of bone fractures; HIP fractures; RESEARCH funding; ALGORITHMS; PROBABILITY theory
- Publication
Journal of Bone & Mineral Metabolism, 2020, Vol 38, Issue 2, p213
- ISSN
0914-8779
- Publication type
journal article
- DOI
10.1007/s00774-019-01046-4