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- Title
Aminopeptidase A inhibitors as centrally acting antihypertensive agents.
- Authors
Laurence Bodineau; Alain Frugière; Yannick Marc; Cédric Claperon; Catherine Llorens-Cortes
- Abstract
Abstract  Among the main bioactive peptides of the brain reninâangiotensin system, angiotensin (Ang) II and AngIII exhibit the same affinity for the type 1 and type 2 Ang receptors. Both peptides, injected intracerebroventricularly, cause similar increase in blood pressure (BP). Because AngII is converted in vivo to AngIII, the identity of the true effector is unknown. This review summarized recent insights into the predominant role of brain AngIII in the central control of BP underlining the fact that brain aminopeptidase A (APA), the enzyme forming central AngIII, could constitute a putative central therapeutic target for the treatment of hypertension. This led to the development of potent, systematically active APA inhibitors, such as RB150, as a prototype of a new class of centrally acting antihypertensive agents for the treatment of certain forms of hypertension.
- Subjects
AMINOPEPTIDASES; ANTIHYPERTENSIVE agents; THERAPEUTICS; HYPERTENSION; ANGIOTENSINS
- Publication
Heart Failure Reviews, 2008, Vol 13, Issue 3, p311
- ISSN
1382-4147
- Publication type
Article
- DOI
10.1007/s10741-007-9077-3