We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of previous heterologous flavivirus vaccinations on human antibody responses in tick‐borne encephalitis and dengue virus infections.
- Authors
Roßbacher, Lena; Malafa, Stefan; Huber, Kristina; Thaler, Melissa; Aberle, Stephan W.; Aberle, Judith H.; Heinz, Franz X.; Stiasny, Karin
- Abstract
Arthropod‐borne flaviviruses include a number of medically relevant human pathogens such as the mosquito‐borne dengue (DEN), Zika, and yellow fever (YF) viruses as well as tick‐borne encephalitis virus (TBEV). All flaviviruses are antigenically related and anamnestic responses due to prior immunity can modulate antibody specificities in subsequent infections or vaccinations. In our study, we analyzed the induction of broadly flavivirus cross‐reactive antibodies in tick‐borne encephalitis (TBE) and DEN patients without or with prior flavivirus exposure through TBE and/or YF vaccination, and determined the contribution of these antibodies to TBE and dengue virus (DENV) neutralization. In addition, we investigated the formation of cross‐reactive antibodies in TBE‐vaccination breakthroughs (VBTs). A TBEV infection without prior YF or TBE vaccination induced predominantly type‐specific antibodies. In contrast, high levels of broadly cross‐reactive antibodies were found in samples from TBE patients prevaccinated against YF as well as in DEN patients prevaccinated against TBE and/or YF. While these cross‐reactive antibodies did not neutralize TBEV, they were effective in neutralizing DENV. This discrepancy points to structural differences between the two viruses and indicates that broadly cross‐reactive epitopes are less accessible in TBEV than in DENV. In TBE VBT infections, type‐specific antibodies dominated the antibody response, thus revealing no difference from that of unvaccinated TBE patients. Our results emphasize significant differences in the structural properties of different flaviviruses that have an impact on the induction of broadly cross‐reactive antibodies and their functional activities in virus neutralization.
- Subjects
TICK-borne encephalitis viruses; VIRUS diseases; ANTIBODY formation; FLAVIVIRUSES; DENGUE viruses
- Publication
Journal of Medical Virology, 2023, Vol 95, Issue 11, p1
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.29245