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- Title
Transforming growth factor‐β family biology: From basic mechanisms to roles in development and disease.
- Authors
Christian, Jan L.; Hill, Caroline S.
- Abstract
Beginning with the ligands, Rifkin et al.1 discuss the latent TGF- binding proteins (LTBPs) with respect to their role in regulating TGF- ligand activity. The transforming growth factor- (TGF- ) family of ligands comprises 33 members in humans, of which 30 are positively acting ligands including the TGF- s, the Activins, the bone morphogenetic proteins (BMPs), the growth and differentiation factors (GDFs) and anti-Mullerian hormone, and 3 are ligand antagonists: inhibin- (INHA), LEFTY1, and LEFTY2. I Tgfbr-3 i encodes the TGF- co-receptor, Betaglycan, which can either facilitate or antagonize ligand-mediated activation of TGF- receptors. Transforming growth factor- family biology: From basic mechanisms to roles in development and disease.
- Subjects
BIOLOGY; GROWTH factors; TRANSFORMING growth factors; BONE morphogenetic proteins; TRANSFORMING growth factors-beta; GROWTH differentiation factors
- Publication
Developmental Dynamics, 2022, Vol 251, Issue 1, p6
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.445