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- Title
Incidence of growth and rupture of unruptured intracranial aneurysms followed by serial MRA.
- Authors
Matsumoto, K.; Oshino, S.; Sasaki, M.; Tsuruzono, K.; Taketsuna, S.; Yoshimine, T.
- Abstract
Background: The natural history, including growth and rupture, of unruptured intracranial aneurysms (UIAs) remains unknown. Here, we present the results of serial magnetic resonance angiography (MRA) follow-up study in 111 patients with 136 UIAs. Method: A total of 111 patients with 136 UIAs were followed annually over the past 12 years, using 1.5-Tesla MRA. Follow-up was ended when UIAs were treated surgically, or the patients died of subarachnoid hemorrhage or other causes. Various factors influencing aneurysm rupture or growth were examined statistically. Results: Aneurysm rupture and growth occurred in six and 13 of the 111 patients, respectively. Annual rupture rate was 1.8 % per year and annual growth rate was 3.9 % per year. Aneurysm size was the sole factor influencing rupture(H.R. 1.214, 95 % CI, 1.078-1.368) and multiplicity was the sole factor influencing aneurysm growth (H.R. 5.174, 95 % CI 1.81-14.80). Conclusions: Serial MRA study showed that the incidence of UIA growth was twice as high as that of UIA rupture. As four patients showed aneurysm rupture or growth within 1 year, further investigations are necessary to determine the optimum interval of radiological investigation and to identify which UIAs grow or rupture within a short time.
- Subjects
INTRACRANIAL aneurysms; SUBARACHNOID hemorrhage; CEREBRAL hemorrhage; ARTERIAL injuries; VASCULAR diseases
- Publication
Acta Neurochirurgica, 2013, Vol 155, Issue 2, p211
- ISSN
0001-6268
- Publication type
Article
- DOI
10.1007/s00701-012-1566-z