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- Title
Cytokine Changes during Warm Ischemia and Reperfusion of the Pig Liver with or without Preconditioning.
- Authors
Kannerup, A.-S.; Grønbæk, H.; Funch-Jensen, P.; Tønnesen, E.; Jørgensen, R. L.; Mortensen, F. V.
- Abstract
Background: Hepatic inflow occlusion results in ischemia-reperfusion injury. The aim of the present porcine study was to investigate whether the pro- and anti-inflammatory cytokine response is involved in mediating the protective effect of ischemic preconditioning (IPC) during, and after warm liver ischemia. Methods: Fifteen randomized pigs – 7 non-IPC and 8 (IPC) – underwent laparotomy followed by 60 min of total ischemia with or without IPC continued by 3 h of reperfusion. Plasma cytokines (IL-6, IL-8, IL-10, and TNF-α) were measured during the study period as well as liver parameters (alanine-aminotransferase, alkaline phosphatase, bilirubin, and prothrombin time). Results: In the IPC group, IL-6 increased significantly during reperfusion compared to baseline and the non-IPC group. TNF-α increased nonsignificantly in the non-IPC group, while the levels remained stable in the IPC group. IL-8 and IL-10 increased in both groups after reperfusion. Only minor differences were observed in liver parameters. Conclusions: Warm liver ischemia with or without IPC activates inflammatory cytokines. IL-6 increased significantly in the IPC group compared to the non-IPC group, while the opposite was observed for TNF-α. These cytokine changes may be involved in the hepatoprotective mechanism induced by IPC. Copyright © 2009 S. Karger AG, Basel
- Subjects
CYTOKINES; ISCHEMIA; REPERFUSION; ABDOMINAL surgery; LIVER
- Publication
European Surgical Research, 2009, Vol 42, Issue 4, p216
- ISSN
0014-312X
- Publication type
Article
- DOI
10.1159/000208520