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- Title
Fulminant puerperal sepsis due to anaplastic large-cell lymphoma (ALCL) with therapy-refractory cerebral edema.
- Authors
Freerksen, Nele; Kirschner, Martin; Pecks, Ulrich; Westphal, Saskia; Jost, Edgar; Maass, Nicolai; Bauerschlag, Dirk
- Abstract
Introduction: Lymphoma is among the five most frequent malignancies during pregnancy while anaplastic large-cell lymphoma (ALCL) is rare, accounting only for 2-3 % of all adult-onset non-Hodgkin lymphomas. Case report: A 23-year-old gravida 1, para 1 presented with puerperal mastitis and septicemia following secondary cesarean section. Mastitis had been present for a week prior to delivery. A CT scan for further diagnostics revealed numerous prominent lymph nodes. Cerebrospinal fluid testing, bone marrow and lymph node biopsy confirmed diagnosis of ALCL. Systemic and intrathecal chemotherapy was initiated, stabilizing the patient's clinical situation. 30 days postpartum (pp.), a cerebral edema was diagnosed responsible for cerebro-venous hypoperfusion. Immediate ventricle drainage and further therapeutic measures revealed no improvement. The patient died 33 days pp. Conclusion: Puerperal septicemia seemingly caused by mastitis still needs rapid further evaluation if the patient's clinical presentation quickly declines despite antibiotic therapy. Immediate initiation of chemotherapy after confirmation of ALCL is required to increase the therapeutic benefit due to the poor prognosis of ALCL.
- Subjects
PUERPERAL septicemia; LYMPHOMAS; CEREBRAL edema; MASTITIS; PREGNANCY complications; CESAREAN section; LYMPH nodes; BONE marrow
- Publication
Archives of Gynecology & Obstetrics, 2014, Vol 290, Issue 1, p191
- ISSN
0932-0067
- Publication type
Case Study
- DOI
10.1007/s00404-014-3171-2