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- Title
EFFECT OF CASTRATION ON CHOLESTEROL METABOLISM AND HEPATIC CYTOCHROME P-450 IN PIPERAZINE-TREATED MALE AND FEMALE RABBITS.
- Authors
West, C. E.; Redgrave, T. G.; Roberts, D. C. K.
- Abstract
Piperazine was added to the diets of cholesterol-fed male and female rabbits that had been castrated 8 weeks previously. Castration did not alter the differential effect of piperazine on cholesterol metabolism, i.e. in male rabbits hypercholesterolaemia was reduced but in females it was augmented. In the same experiments hepatic microsomal cytochrome P-450 was measured. Intact female rabbits had higher P-450 concentration than males and the difference was removed after castration. Piperazine reduced P-450 concentration in males but not in females. We conclude that the differential effect of piperazine on cholesterol metabolism in male and female rabbits must operate at a chromosomal or somatic level of sexual differentiation and not through the gonad. There is no simple relationship between hepatic total P-450 concentration and cholesterol metabolism.
- Subjects
CASTRATION; GENITAL surgery; LIVER cells; HYPERCHOLESTEREMIA; PIPERAZINE; LABORATORY rabbits
- Publication
Australian Journal of Experimental Biology & Medical Science, 1974, Vol 52, Issue 1, p185
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1974.15