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- Title
Local and Systemic Functional Responses of Mouse Macrophages to Intravaginal Infection with Type 2 Herpes Simplex Virus and Vaccination.
- Authors
Zaitseva, L.; Bekhalo, V.; Kireeva, I.; Shaposhnikova, G.; Nagurskaya, E.; Barinskii, I.; Nesterenko, V.
- Abstract
Activity of cathepsin D and phagocytosis of macrophages from vaginal lavage fluid, peritoneal exudation, and spleen were studied in mice of sensitive (DBA/2) and resistant (BALB/c) lines after intravaginal infection with type 2 herpes simplex virus and vaccination. Activity of cathepsin D and intensity of phagocytosis (irrespective of the macrophage source) and their ratio in BALB/c mice in early terms after infection were close to the control levels taken as a unit. In DBA/2 mice, these parameters and their balance were shifted and changes in cathepsin D activity depended on the time after challenge. Activities of cellular and extracellular cathepsin D increased sharply on day 1 postinfection under conditions of local virus interaction with the vaginal mucosa and activation of the pathological process. Later, after generalization of the infection, activity of cathepsin D decreased, while phagocytosis increased in all the studied macrophage populations. Vaccination corrected the cathepsin D/phagocytosis imbalance and created conditions for rapid elimination of the virus.
- Subjects
MACROPHAGES; PHAGOCYTOSIS; VAGINAL douching; CATHEPSIN D; HERPES simplex vaccines
- Publication
Bulletin of Experimental Biology & Medicine, 2017, Vol 163, Issue 1, p68
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-017-3740-z