We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protective effects of curcumin and/or aerobic exercise on myocardial injury in hyperlipidemic rats.
- Authors
WANG Li; ZHOU Qiyun; QIN Fei; ZHOU Haitao; ZHANG Jing; ZHANG Xinyue; LIU Xiaoxue; QIN Siyang
- Abstract
To study the protective effects of curcumin and/or aerobic exercise on myocardial injury in hyperlipidemia rats, the hyperlipidemia rat model was used. Curcumin and/or aerobic exercise was used to intervene the rats for 6 weeks. The myocardial histomorphology of rats in each group was observed, and blood lipid levels, serum cardiac troponin I (cTnI) levels, myocardial tumor necrosis factor-α (TNF-α) levels and silent mating type information regulation 2 homolog 1 (SIRT1)/nuclear factor-kappa B (NF-κB) signaling pathway-related protein expression levels were detected. The results showed that curcumin and/or aerobic exercise improved dyslipidemia significantly, reduced serum cTnI and myocardial TNF-α levels, upregulated myocardial SIRT1 protein expression, downregulated myocardial NF-κB and Ac-NF-κB protein expression, alleviated the extent of myocardial injury. Among them, the combined intervention was the most effective. The results suggested that 6 weeks of curcumin and/or aerobic exercise intervention reduced the inflammation level of cardiomyocytes effectively and alleviated myocardial injury in hyperlipidemic rats, and the mechanism of its protective effect might be related to the regulation of SIRT1/NF-κB signaling pathway-related protein expression and inhibition of inflammatory response.
- Subjects
MYOCARDIAL injury; AEROBIC exercises; CURCUMIN; SIRTUINS; EXERCISE therapy; BLOOD lipids
- Publication
China Food Additives, 2023, Vol 34, Issue 2, p156
- ISSN
1006-2513
- Publication type
Article
- DOI
10.19804/j.issn1006-2513.2023.02.020