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- Title
Increased choroidal thickness in adults with Down syndrome.
- Authors
Csincsik, Lajos; Nelson, Rachel; Walpert, Madeleine J.; Peto, Tunde; Holland, Anthony; Lengyel, Imre
- Abstract
Introduction: People with Down syndrome (DS) are particularly susceptible to Alzheimer’s disease (AD) due to the triplication of the amyloid precursor protein (APP) gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS. Methods: The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl)were imaged with optical coherence tomography. Choroidal thickness (ChT) was measured and analyzed in relation to cognitive status and cerebral amyloid beta (Aβ) load. Results: ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlatedwith cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status. Discussion: In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.
- Subjects
PEOPLE with Down syndrome; ALZHEIMER'S disease; AMYLOID beta-protein precursor; CHOROID diseases; OPTICAL coherence tomography; DEMENTIA
- Publication
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021, Vol 13, Issue 1, p1
- ISSN
2352-8729
- Publication type
Article
- DOI
10.1002/dad2.12170