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- Title
Glibenclamide Increases Nitric Oxide Levels and Decreases Oxidative Stress in an In Vitro Model of Preeclampsia.
- Authors
Nunes, Priscila Rezeck; Bueno Pereira, Thaina Omia; Bertozzi Matheus, Mariana; Grandini, Nubia Alves; Siqueira, Juliana Silva; Correa, Camila Renata; Abbade, Joelcio Francisco; Sandrim, Valeria Cristina
- Abstract
Keywords: glibenclamide; preeclampsia; nitric oxide; reactive oxygen species; antioxidant capacity; HUVEC EN glibenclamide preeclampsia nitric oxide reactive oxygen species antioxidant capacity HUVEC N.PAG N.PAG 12 08/29/22 20220801 NES 220801 1. Figures and Table Graph: Figure 1 There were no differences in HUVEC viability between treatment with glibenclamide (GB) or the combination of GB (50, 100, and 200 µM) plus plasma of NT (n = 10) and PE (n = 10) pregnant women for 24 h. Supernatant Levels of MDA Indicate a Decrease in Lipid Peroxidation in GB-Treated Cells... The cells incubated with GB showed lower levels of MDA in the supernatant ( I p i < 0.05) when compared with cultures with only pooled PE plasma (Figure 5).
- Subjects
PREECLAMPSIA; OXIDATIVE stress; POTASSIUM channels; NITRIC oxide; TROPHOBLAST; GLIBENCLAMIDE; PERSISTENT fetal circulation syndrome; THIOBARBITURIC acid test
- Publication
Antioxidants, 2022, Vol 11, Issue 8, pN.PAG
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11081620