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- Title
Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer's Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study.
- Authors
Postu, Paula Alexandra; Gorgan, Dragos Lucian; Cioanca, Oana; Russ, Manuela; Mikkat, Stefan; Glocker, Michael Otto; Hritcu, Lucian
- Abstract
Origanum L. (Lamiaceae) is an important genus of medicinal and aromatic plants used in traditional medicine since ancient times as culinary herbs and remedies. The aim of the present study was to evaluate the chemical composition, as well as the biochemical and cellular activities of freshly prepared Origanum majorana L. essential oil (OmEO) in an Alzheimer's disease (AD) amyloid beta1-42 (Aβ1-42) rat model. OmEO (1% and 3%) was inhaled for 21 consecutive days, while Aβ1-42 was administered intracerebroventricularly to induce AD-like symptoms. Our data demonstrate that OmEO increased antioxidant activity and enhanced brain-derived neurotrophic factor (BDNF) expression, which in concert contributed to the improvement of cognitive function of animals. Moreover, OmEO presented beneficial effects on memory performance in Y-maze and radial arm-maze tests in the Aβ1-42 rat AD model.
- Subjects
ORIGANUM; BRAIN-derived neurotrophic factor; ESSENTIAL oils; MOLECULAR models; HUMAN behavior models; AMYLOID; AROMATIC plants; SALVIA
- Publication
Antioxidants, 2020, Vol 9, Issue 10, p919
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox9100919