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- Title
The quest for genetic determinants of human longevity: challenges and insights.
- Authors
Christensen, Kaare; Johnson, Thomas E.; Vaupel, James W.
- Abstract
Twin studies show that genetic differences account for about a quarter of the variance in adult human lifespan. Common polymorphisms that have a modest effect on lifespan have been identified in one gene, APOE, providing hope that other genetic determinants can be uncovered. However, although variants with substantial beneficial effects have been proposed to exist and several candidates have been put forward, their effects have yet to be confirmed. Human studies of longevity face numerous theoretical and logistical challenges, as the determinants of lifespan are extraordinarily complex. However, large-scale linkage studies of long-lived families, longitudinal candidate-gene association studies and the development of analytical methods provide the potential for future progress.
- Subjects
LONGEVITY; LIFE spans; HUMAN life cycle; GENETICS; BIOLOGY; ALLELES; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; EVALUATION research
- Publication
Nature Reviews Genetics, 2006, Vol 7, Issue 6, p436
- ISSN
1471-0056
- Publication type
journal article
- DOI
10.1038/nrg1871