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- Title
Blindness following bleb-related infection in open angle glaucoma.
- Authors
Yamada, Hiroki; Sawada, Akira; Yamamoto, Tetsuya; Kuwayama, Yasuaki
- Abstract
Purpose: To estimate the risk of blindness following bleb-related infection after trabeculectomy with mitomycin C in open angle glaucoma, utilizing data obtained from two prospective multicenter studies. Methods: The incidence of bleb-related infection in open angle glaucoma after the first or second glaucoma surgery was calculated using a Kaplan-Meier analysis and data from the Collaborative Bleb-related Infection Incidence and Treatment Study (CBIITS). The rate of blindness following bleb-related infection was calculated using data from the Japan Glaucoma Society Survey of Bleb-related Infection (JGSSBI). Finally, the rate of blindness following bleb-related infection after filtering surgery was estimated based on the above two data sets. Blindness was defined as an eye with a visual acuity of 0.04 or less. Results: The incidences of development of bleb-related infection at 5 years were 2.6 ± 0.7 % (calculated cumulative incidence ± standard error) for all infections and 0.9 ± 0.4 % for endophthalmitis in all cases in the CBIITS data. The rates of blindness in the JGSSBI data were 14 % for the total cases with bleb-related infection and 30 % for the endophthalmitis subgroup. The rate of blindness developing within 5 years following trabeculectomy was estimated to be approximately 0.24-0.36 %. Conclusions: The rate of blindness following bleb-related infection within 5 years after trabeculectomy is considerable and thus careful consideration must be given to the indication for trabeculectomy and the selection of surgical techniques.
- Subjects
BLEBS (Cytology); BLINDNESS; GLAUCOMA; MITOMYCIN C; INTRAOCULAR pressure; OPHTHALMIC surgery
- Publication
Japanese Journal of Ophthalmology, 2014, Vol 58, Issue 6, p490
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-014-0346-0