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- Title
Ethylene glycol poisoning.
- Authors
Bates, Nicola
- Abstract
Ethylene glycol, which is most commonly encountered in antifreeze, causes acidosis and renal failure and is a frequent cause of lethal poisoning in companion animals, particularly cats. Initial signs including neurological effects and vomiting are non-specific and may be overlooked. Signs progress as renal failure develops. The aims of therapy in ethylene glycol poisoning are to prevent metabolism of the parent compound and the production of toxic metabolites, typically through the use of ethanol; reverse electrolyte and acid/ base disturbances; and maintain the glomerular filtration rate. Antidotal therapy should be started as soon as possible after ingestion for the best chance of survival, because ethylene glycol is rapidly absorbed and metabolised, and once renal failure occurs treatment options are limited. Haemodialysis can be effective but is rarely available. Prognosis is poor in animals with renal failure, seizures or coma.
- Subjects
ETHYLENE glycol; ANTIFREEZE solutions; GLOMERULAR filtration rate; ETHANOL; KIDNEY failure
- Publication
UK-Vet Companion Animal, 2016, Vol 21, Issue 2, p95
- ISSN
2053-0889
- Publication type
Article
- DOI
10.12968/coan.2016.21.2.95