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- Title
Metabolomic Determinants of Metabolic Risk in Mexican Adolescents.
- Authors
Perng, Wei; Hector, Emily C.; Song, Peter X.K.; Tellez Rojo, Martha Maria; Raskind, Sasha; Kachman, Maureen; Cantoral, Alejandra; Burant, Charles F.; Peterson, Karen E.
- Abstract
<bold>Objective: </bold>The goal of this study was to identify metabolites associated with metabolic risk, separately by sex, in Mexican adolescents.<bold>Methods: </bold>Untargeted metabolomic profiling was carried out on fasting serum of 238 youth aged 8 to 14 years, and metabolites associated with a metabolic syndrome risk z-score (MetRisk z-score) were identified separately for boys and girls, using the simulation and extrapolation algorithm. Associations of each metabolite with MetRisk z-score were examined using linear regression models that accounted for maternal education, child's age, and pubertal status.<bold>Results: </bold>Of the 938 features identified in metabolomics analysis, 7 named compounds (of 27 identified metabolites) were associated with MetRisk z-score in girls, and 3 named compounds (of 14 identified) were associated with MetRisk z-score in boys. In girls, diacylglycerol (DG) 16:0/16:0, 1,3-dielaidin, myo-inositol, and urate corresponded with higher MetRisk z-score, whereas N-acetylglycine, thymine, and dodecenedioic acid were associated with lower MetRisk z-score. For example, each z-score increment in DG 16:0/16:0 corresponded with 0.60 (95% CI: 0.47-0.74) units higher MetRisk z-score. In boys, positive associations of DG 16:0/16:0, tyrosine, and 5'-methylthioadenosine with MetRisk z-score were found.<bold>Conclusions: </bold>Metabolites on lipid, amino acid, and carbohydrate metabolism pathways are associated with metabolic risk in girls. Compounds on lipid and DNA pathways correspond with metabolic risk in boys.
- Subjects
METABOLITE analysis; METABOLIC syndrome diagnosis; MEXICAN American teenagers; ADOLESCENT health; CHEMILUMINESCENCE analyzers; HEALTH; RESEARCH funding
- Publication
Obesity (19307381), 2017, Vol 25, Issue 9, p1594
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.21926