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- Title
Relationships Between IGF-1 and IGFBP-1 and Adiposity in Obese African-American and Latino Adolescents.
- Authors
Alderete, Tanya L.; Byrd-Williams, Courtney E.; Toledo-Corral, Claudia M.; Conti, David V.; Weigensberg, Marc J.; Goran, Michael I.
- Abstract
The purpose of this study was to examine interrelationships between insulin-like growth factor 1 (IGF-1), IGF binding proteins (IGFBPs), and adiposity in 49 African-American and 77 Latino obese adolescents (15.3 ± 0.1 and 15.4 ± 0.2 years; BMI: 33.0 ± 0.7 and 35.0 ± 1.0 kg/m2, respectively). Immunoradiometric assays were used to measure IGF-1, IGFBP-1, and IGFBP-3. Total fat and soft lean tissue were measured by dual-energy X-ray absorptiometry and visceral adipose tissue (VAT), subcutaneous abdominal adipose tissue (SAAT), and hepatic fat fraction (HFF) were measured by magnetic resonance imaging. IGF-1 levels were 23.1% higher and IGFBP-1 were 40.4% higher in African Americans compared to Latinos after adjustment for total lean and total fat mass. IGF-1 and IGFBP-1 were inversely correlated with BMI, total fat mass, VAT, and HFF (r = −0.20 to −0.33, P < 0.05) while IGFBP-1 was inversely correlated with SAAT (r = −0.22, P < 0.05). These relationships did not differ by ethnicity, however, the relationship between IGF-1 and SAAT, as well as IGFBP-1 and HFF, differed by ethnicity. Predicted mean IGF-1 levels were 30.7% higher for African Americans at the 75th compared to 25th percentile of SAAT and only 11.7% higher for Latinos. Predicted mean IGFBP-1 levels were 158% higher for African Americans at the 25th compared to the 75th percentile of HFF while IGFBP-1 levels were 1.7% higher for Latinos at the 75th compared to the 25th percentile. These results demonstrate that the relationship between IGF-1 and SAAT as well as IGFBP-1 and HFF are different in African-American and Latino adolescents and may contribute to the higher IGF-1 levels in African-Americans.
- Subjects
INSULIN-like growth factor-binding proteins; SOMATOMEDIN; OBESITY; HEALTH of African Americans; OVERWEIGHT teenagers; HISPANIC Americans
- Publication
Obesity (19307381), 2011, Vol 19, Issue 5, p933
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1038/oby.2010.211