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- Title
Phosphonoacetate biosynthesis: In vitro detection of a novel NADP-dependent phosphonoacetaldehyde-oxidizing activity in cell-extracts of a marine Roseobacter.
- Authors
Cooley, N. A.; Kulakova, A .N.; Villarreal-Chiu, J. F.; Gilbert, J. A.; McGrath, J. W.; Quinn, J. P.
- Abstract
novel phosphonoacetaldehyde-oxidizing activity was detected in cell-extracts of the marine bacterium Roseovarius nubinhibens ISM grown on 2-aminoethylphosphonic acid (2-AEP; ciliatine). Extracts also contained 2-AEP transaminase and phosphonoacetate hydrolase activities. These findings indicate the existence of a biological route from 2-AEP via phosphonoacetaldehyde for the production of phosphonoacetate, which has not previously been shown to be a natural product. The three enzymes appear to constitute a previously-unreported pathway for the mineralization of 2-AEP which is a potentially important source of phosphorus in the nutrient-stressed marine environment.
- Subjects
BIOSYNTHESIS; MARINE bacteria; HYDROLASES; BIOCHEMISTRY; BIOCHEMICAL engineering
- Publication
Microbiology (00262617), 2011, Vol 80, Issue 3, p335
- ISSN
0026-2617
- Publication type
Article
- DOI
10.1134/S0026261711030076