We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of T cell immune response cDNA 7 on the pathology of acute graft-versus-host disease.
- Authors
Zhu, Feng; Xu, Yanqiu; Fan, Xiaohui; Zhang, Fan; Wang, Dong; Qiao, Jianlin; Zhu, Shengyun; Zhao, Kai; Pan, Bin; Chen, Chong; Zeng, Lingyu; Li, Zhenyu; Xu, Kailin
- Abstract
Activation of T lymphocytes is the initiating factor of the occurrence of acute graft-versus-host disease (aGVHD), and cytotoxic T lymphocyte antigen-4 (CTLA-4) is the inhibitory receptor for activating T cells. T cell immune response cDNA 7 (TIRC7) is considered an upstream regulator of CTLA-4; however, little is understood regarding the effects of TIRC7 on the regulation of CTLA-4 in aGVHD. The purpose of the present study was to evaluate the regulatory effects of TIRC7 on aGVHD, mainly in the pathology. Recipient mice were exposed to a preconditioning dose of 7.5 Gy irradiation on the day of the transplantation and were divided into the following groups: Blank control group, bone marrow transplantation control group, total body irradiation group, mild-moderate aGVHD group and severe aGVHD group. According to the different administration of CTLA-4 and TIRC7 monoclonal antibodies, the mild-moderate and severe aGVHD groups were randomly divided into the hematopoietic stem cell transplantation (HSCT) and HSCT + CTLA-4/TIRC7 groups. Recipient mice were sacrificed at different time points post-HSCT for histopathological analysis by hematoxylin and eosin staining. Compared with the control and other experimental groups, the mice in the combined CTLA-4 and TIRC7 group exhibited ameliorated pathological injury, and lower pathology scores of the liver, lung and intestine. These data revealed that intraperitoneal injection of anti-TIRC7 and/or anti-CTLA-4 monoclonal antibody into mice could effectively alleviate the severity of aGVHD.
- Subjects
CYTOTOXIC T lymphocyte-associated molecule-4; GRAFT versus host disease; T cells; HEMATOPOIETIC stem cell transplantation; ACUTE diseases; RADIATION injuries
- Publication
Oncology Letters, 2020, Vol 20, Issue 6, pN.PAG
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2020.12163