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- Title
Circular RNAs in gastric cancer: Biomarkers for early diagnosis.
- Authors
Yang, Chun-Mei; Qiao, Guang-Lei; Song, Li-Na; Bao, Shisan; Ma, Li-Jun
- Abstract
Circular RNAs (circRNAs) are highly conserved and stable closed-loop non-coding RNAs. They are involved in numerous biological functions, including regulating gene transcription or protein translation by interacting with proteins and regulating expression of microRNAs. The aberrant expression of circRNAs has been reported in many cancers, including gastric cancer. By regulating gene expression, circRNAs are able to affect the proliferation, invasion and metastasis of gastric cancer. The current review focused on the characteristics and biological functions of circRNAs, the carcinogenic potential and the possible implications of circRNAs on the diagnosis and treatment of gastric cancer. In conclusion, circRNAs may serve as potential biomarkers for diagnosis, as well as therapeutic targets.
- Subjects
CIRCULAR RNA; STOMACH cancer; EARLY diagnosis; BIOMARKERS; PROTEIN expression
- Publication
Oncology Letters, 2020, Vol 20, Issue 1, p465
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2020.11623