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- Title
The prognostic value of neutrophil to lymphocyte and platelet to lymphocyte ratios for patients with lung cancer.
- Authors
Liqun Wang; Di Liang; Xiaoli Xu; Jing Jin; Shumei Li; Guo Tian; Zhaoyu Gao; Congmin Liu; Yutong He
- Abstract
As the leading cause of cancer‑associated mortality globally among males in 2012, lung cancer is a disease of particular concern. Previously, the neutrophil‑to‑lymphocyte ratio (NLR) and the platelet‑to‑lymphocyte ratio (PLR) were revealed to be prognostic factors for various types of cancer, including lung cancer. In the present study, a retrospective review was conducted with patients who were diagnosed with lung cancer between January 1, 2000 and December 31, 2005 in the Fourth Hospital of Hebei Medical University. A total of 695 patients were included, and the optimal cutoffs of the NLR and the PLR were 6.0 and 248.0, respectively. There were statistically significant associations between tumor‑node‑metastasis (TNM) stage, surgery, metastasis incidence and NLR (P<0.001). The associations between TNM stage, surgery incidence and PLR were also revealed to be statistically significant (P<0.001). Patients in the low NLR group demonstrated longer overall survival (OS) than patients in the high NLR group (819.57 days vs. 629.86 days, P=0.041). The NLR at diagnosis was demonstrated to be an independent prognostic factor for OS. Thus, the NLR may be a promising approach for predicting the prognosis of patients with lung cancer.
- Subjects
LUNG cancer; LYMPHOCYTE count; CANCER patients; DNA damage; LEUCOCYTE elastase; NEUTROPHILS
- Publication
Oncology Letters, 2017, Vol 14, Issue 6, p6449
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2017.7047