We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Regeneration of optic nerve fibers of adult mammals.
- Authors
Watanabe, Masami
- Abstract
The pathway from the retina to the brain in mammals provides a well-defined model system for investigation of not only surviving axotomy but also axonal regeneration of injured neurons. Here I introduce our recent works on axonal regeneration in the optic nerve (OpN) of adult cats. Fibers of retinal ganglion cells (RGCs) extend beyond the crush site of OpN with injections of a macrophage stimulator (oxidized galectin-1) or a Rho kinase (ROCK) inhibitor (Y-39983 or Y-27632) while axonal extension is blocked with injection of saline. Elongation of crushed optic fibers, however, is slowed after 2 weeks. Transplantation of peripheral nerve makes RGCs regenerate their transected axons into a graft but regenerated fibers extend only a few mm in the brain. Effectiveness of combination of the drugs and treatments has to be verified in future.
- Subjects
OPTIC nerve cytology; NERVOUS system regeneration; RETINAL ganglion cells; VISUAL pathways; MAMMAL anatomy; OPTIC nerve
- Publication
Development, Growth & Differentiation, 2010, Vol 52, Issue 7, p567
- ISSN
0012-1592
- Publication type
Article
- DOI
10.1111/j.1440-169X.2010.01203.x