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- Title
Lack of evidence that inactivation of the mouse X-chromosome is incomplete.
- Authors
Lyon, Mary F.
- Abstract
The fact that the X-linked genes scurfy (sf) and sparse-fur (spf) of the mouse do not produce a mosaic effect in heterozygotes had been taken, by other workers, together with results from X-Autosome translocations, as evidence that inactivation of the mouse X was incomplete. In this paper it is argued that absence of a mosaic effect is not adequate evidence that a gene is not inactivated. The argument was backed by an experiment in which the spf gene was introduced heterozygously into females carrying an X-linked translocation resulting in non-random X-inactivation with the same X active in all cells. When the mutant (spf) allele was on the active X its effect was fully expressed, indicating that the normal allele on the structurally normal inactive X was undergoing inactivation. Argument is further presented that results from X-Autosome translocations do not indicate the degree of completeness of inactivation in a structurally normal X. Hence, there is no evidence that inactivation of the mouse X is incomplete, although evidence from XO females does suggest that it may be incomplete in man.
- Publication
Genetics Research, 1966, Vol 8, Issue 2, p197
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300010053