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- Title
Anti-Inflammatory Flavonolignans from Triticum aestivum Linn. Hull.
- Authors
Han, Ah-Reum; Kil, Yun-Seo; Hong, Min Jeong; Park, Jisu; Park, Hyeon Hwa; Jin, Chang Hyun; Nam, Joo-Won; Kim, Jin-Baek
- Abstract
Wheat (Triticum aestivum Linn.; Poaceae) is a very common and important food grain and ranks second in total cereal crop production. A large amount of wheat hull is produced after threshing that, as the non-food part of wheat, is agro-waste, accounting for 15~20% of the wheat. This study aimed at biologically and phytochemically investigating wheat hull for its valorization as a by-product. In our ongoing search for natural product-derived anti-inflammatory agents, T. aestivum hull was evaluated for its nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-activated RAW 264.7 cells, and the phytochemical investigation of the ethyl acetate fraction showing inhibitory effect led to the isolation of a flavone (1) and seven flavonolignans (2–8). Compounds 2–8 have not yet been isolated from Triticum species. All compounds were evaluated for their LPS-induced NO production inhibition, and 1, 2, 4, 6, and 8 exhibited inhibitory effects with IC50 values ranging from 24.14 to 58.95 μM. These results suggest the potential of using T. aestivum hull as a source for producing anti-inflammatory components, enhancing its valorization as a by-product.
- Subjects
WHEAT; RICE hulls; AGRICULTURAL productivity; ETHYL acetate; GRASSES; ANTI-inflammatory agents
- Publication
Applied Sciences (2076-3417), 2020, Vol 10, Issue 23, p8656
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app10238656