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- Title
Biopsy‐based single‐cell transcriptomics reveals MAIT cells as potential targets for controlling fibrosis‐related liver inflammation due to chronic hepatitis‐B infection.
- Authors
Shao, Li; Zhao, Hong; Guo, Rongfang; Cheng, Jinlin; Lu, Xiaoyan; Fan, Xiaohui
- Abstract
(F) Developmental trajectory for differential T cell subclusters gl We further confirmed the presence of two MAIT cell populations by immunofluorescence, and annotated them as I CD3 i SP + sp I SLC4A10 i SP + sp I TNFAIP3 i SP + sp (T7) and I CD3 i SP + sp I SLC4A10 i SP + sp I TNFAIP3 i SP - sp (T6) MAIT cells (Figure 3). Inspired from the decrease of MAIT cells and increased ratio of T6 versus T7 during liver inflammation progression, MAIT cells may act as a potential target for controlling HBV-related liver inflammation in future studies. Biopsy-based single-cell transcriptomics reveals MAIT cells as potential targets for controlling fibrosis-related liver inflammation due to chronic hepatitis-B infection In conclusion, our study reported the remodelling of T cell subpopulations and the presence of two MAIT cell populations that may contribute to HBV-related liver inflammation for the first time.
- Subjects
LIVER histology; HEPATITIS; HEPATITIS B
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 10, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1073