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- Title
Incidence, predictors, and prognosis of thrombocytopenia among patients undergoing intra-aortic balloon pumping in the intensive care unit: a propensity score analysis.
- Authors
TONG, Wei; WANG, Jun-Mei; LI, Jia-Yue; LI, Pei-Yao; CHEN, Yun-Dai; ZHANG, Zheng-Bo; DONG, Wei
- Abstract
OBJECTIVE• To explore the incidence, predictors, and prognosis of intra-aortic balloon pumping (IABP)-related thrombocytopenia in critically ill patients. METHODS• This multi-center study used the eICU Collaborative Research Database V1.2, comprising data on > 130,000 patients from multiple intensive care units (ICUs) in America between 2014 and 2015. A total of 710 patients undergoing IABP were included. Thrombocytopenia was defined as a drop in platelet count > 50% from baseline. From the cohort, 167 patients who developed thrombocytopenia were matched 1:1 with 167 patients who did not, after propensity score (PS) matching. The associations between IABP-related thrombocytopenia and clinical outcomes were examined by multivariable logistic regression. RESULTS• Among 710 patients undergoing IABP, 249 patients (35.07%) developed thrombocytopenia. The APACHE IVa score was a predictor of thrombocytopenia [adjusted odds ratio (OR) = 1.09, 95% confidence interval (CI): 1.02-1.15]. After 1:1 PS matching, in-hospital mortality (adjusted OR = 0.76, 95% CI: 0.37-1.56) and in-ICU mortality (adjusted OR = 0.74, 95% CI: 0.34-1.63) were similar between the thrombocytopenia and non-thrombocytopenia groups. However, major bleeding occurred more frequently in the thrombocytopenia group (adjusted OR = 2.54, 95% CI: 1.54-4.17). In-hospital length of stay (LOS) and in- ICU LOS were significantly longer in patients who developed thrombocytopenia than in those who did not (9.71 vs. 7.36, P < 0.001; 5.13 vs. 2.83, P < 0.001). CONCLUSIONS• Among patients undergoing IABP in the ICUs, thrombocytopenia was not associated with a difference in inhospital mortality or in-ICU mortality; however, thrombocytopenia was significantly associated with a greater risk of major bleeding and increased in-ICU and in-hospital LOS.
- Subjects
THROMBOCYTOPENIA; INTRA-aortic balloon counterpulsation; INTENSIVE care units; PROPENSITY score matching; CONFIDENCE intervals
- Publication
Journal of Geriatric Cardiology, 2021, Vol 18, Issue 2, p123
- ISSN
1671-5411
- Publication type
Article
- DOI
10.11909/j.issn.1671-5411.2021.02.003